Cardiac Transplantation and Surgery for Heart Failure Post–Heart Transplant Survival Is Inferior at Low-Volume Centers Across All Risk Strata

Background—Previous studies have demonstrated a relationship between increasing center volume and cardiac transplant outcomes. The purpose of this study was to confirm a relationship between post–heart transplant outcomes and center experience and to determine whether this relationship persists among lowand high-risk heart transplant recipient–donor pairs. Methods and Results—The United Network for Organ Sharing (UNOS) provided deidentified patient-level data. Analysis included 8029 heart transplant recipients aged 18 years and transplanted between January 1, 2001 and December 31, 2006 with follow-up available through February 3, 2009. The primary outcome was observed 1-year posttransplant graft survival. Multivariable logistic regression was used to calculate expected 1-year survival for recipients. Threshold analysis identified 3 discrete risk groups of transplant recipients: high-risk, moderate-risk, and low-risk. Three discrete risk strata for center volume: low ( 10.5 recipients/yr), intermediate (10.5 to 47 recipients/yr), and high ( 47 recipients/yr) were also identified. 2 test was used to compare 1-year survival at lowand intermediatewith high-volume centers. In multivariable logistic regression analysis, annual center volume was significantly associated with posttransplant graft survival at 1 year (odds ratio [OR] 0.995, 0.992 to 0.999; P 0.010) and primary graft failure (OR 0.985, 0.972 to 0.997; P 0.015), but not stroke (OR 0.996, 0.990 to 1.003; P 0.295), infection (OR 1.001, 0.998 to 1.003; P 0.613), or dialysis (OR 1.001, 0.997 to 1.005; P 0.522). Log-rank test demonstrated significant difference in survival between volume groups with respect to high-risk (P 0.0032) and low-risk (P 0.00415), but not moderate-risk (P 0.128) patients. Conclusions—A direct relationship existed between increasing center volume and improved graft survival. Across all recipient–donor pair risk strata, posttransplant graft survival at 1 year was significantly lower at low-volume centers. The volume–outcomes relationship was strongest in the highest-risk recipient–donor category. (Circulation. 2010;122[suppl 1]:S85–S91.)